Document Detail


Headache in mild-to-moderate hypertension and its reduction by irbesartan therapy.
MedLine Citation:
PMID:  10847258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although it is generally acknowledged to be a problem in severe hypertension, headache has not been consistently associated with mild-to-moderate hypertension. PATIENTS AND METHODS: In 7 randomized, double-blind, placebo-controlled trials, which included 2,673 patients with mild-to-moderate hypertension (defined as seated diastolic blood pressure of 95-110 mm Hg), patients were randomized to receive once-daily treatment with irbesartan, an angiotensin II receptor blocker (n= 1,987), or placebo (n=686). The data were pooled and analyzed retrospectively to determine whether the level of hypertension was associated with headache and whether antihypertensive therapy reduced the incidence of headache. RESULTS: Factors found to be predictive of headache incidence were diastolic blood pressure, sex (female), and age (<50 years). In comparison with placebo, the use of irbesartan was associated with a significant reduction in the incidence of headache (P=.003). CONCLUSIONS: These data suggest that mild-to-moderate hypertension is not asymptomatic and that the incidence of headache can be reduced by antihypertensive treatment with a favorable adverse effect profile.
Authors:
L Hansson; D H Smith; R Reeves; P Lapuerta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  160     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1654-8     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Hypertension Research, Institute for Geriatrics, Uppsala Universitet, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / adverse effects,  therapeutic use*
Biphenyl Compounds / adverse effects,  therapeutic use*
Female
Headache / drug therapy*,  epidemiology,  etiology
Humans
Hypertension / complications,  drug therapy*
Incidence
Logistic Models
Male
Middle Aged
Prognosis
Randomized Controlled Trials as Topic
Retrospective Studies
Tetrazoles / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Tetrazoles; 138402-11-6/irbesartan
Comments/Corrections
Comment In:
Arch Intern Med. 2001 Mar 12;161(5):775-6   [PMID:  11231724 ]

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