| Headache in mild-to-moderate hypertension and its reduction by irbesartan therapy. | |
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MedLine Citation:
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PMID: 10847258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although it is generally acknowledged to be a problem in severe hypertension, headache has not been consistently associated with mild-to-moderate hypertension. PATIENTS AND METHODS: In 7 randomized, double-blind, placebo-controlled trials, which included 2,673 patients with mild-to-moderate hypertension (defined as seated diastolic blood pressure of 95-110 mm Hg), patients were randomized to receive once-daily treatment with irbesartan, an angiotensin II receptor blocker (n= 1,987), or placebo (n=686). The data were pooled and analyzed retrospectively to determine whether the level of hypertension was associated with headache and whether antihypertensive therapy reduced the incidence of headache. RESULTS: Factors found to be predictive of headache incidence were diastolic blood pressure, sex (female), and age (<50 years). In comparison with placebo, the use of irbesartan was associated with a significant reduction in the incidence of headache (P=.003). CONCLUSIONS: These data suggest that mild-to-moderate hypertension is not asymptomatic and that the incidence of headache can be reduced by antihypertensive treatment with a favorable adverse effect profile. |
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Authors:
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L Hansson; D H Smith; R Reeves; P Lapuerta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 160 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1654-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Clinical Hypertension Research, Institute for Geriatrics, Uppsala Universitet, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / adverse effects, therapeutic use* Biphenyl Compounds / adverse effects, therapeutic use* Female Headache / drug therapy*, epidemiology, etiology Humans Hypertension / complications, drug therapy* Incidence Logistic Models Male Middle Aged Prognosis Randomized Controlled Trials as Topic Retrospective Studies Tetrazoles / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Tetrazoles; 138402-11-6/irbesartan |
| Comments/Corrections | |
Comment In:
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Arch Intern Med. 2001 Mar 12;161(5):775-6
[PMID:
11231724
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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