Document Detail

Head-to-head comparison of two online nomograms for prostate biopsy outcome prediction.
MedLine Citation:
PMID:  20883487     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: • To compare the diagnostic accuracy of two previously validated prostate cancer risk predictors on biopsy.
PATIENTS AND METHODS: • In total, 390 consecutive patients submitted to 10-core systematic transrectal prostate biopsy at our institution were included in this retrospective study. • External validation of a European (European Randomized Study of Screening for Prostate Cancer derived Prostate Risk Indicator; SWOP-PRI) and a North American (Prostate Cancer Prevention Trial Cancer Risk Calculator; PCPT-CRC) nomogram was performed. • The predictive accuracy of these online available nomograms was calculated based on the area under the curve derived from receiver-operator characteristic curves and then compared using the DeLong method.
RESULTS: • Both tools were confirmed to be superior to prostate-specific antigen alone. Moreover, the SWOP-PRI (77.9%) displays a 7.96% increase in the predictive accuracy compared to the PCPT-CRC (69.9%) in a statistically significant fashion (P= 0.002).
CONCLUSIONS: • The results obtained in the present study confirm the utility of nomograms with respect to biopsy outcome prediction in patients with suspicion of prostate cancer. • In the current sample of patients, the European-based nomogram appears to be more accurate than the North American nonogram, which lacks information regarding prostate volume and prostatic ultrasonographic lesions. • To our knowledge, this is the first study to compare the accuracy of these popular risk calculators in a specific population.
Mário Oliveira; Vera Marques; António Pedro Carvalho; Américo Santos
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Publication Detail:
Type:  Journal Article     Date:  2010-09-30
Journal Detail:
Title:  BJU international     Volume:  107     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1780-3     Citation Subset:  IM    
Copyright Information:
Department of Urology, Hospital de Braga, Braga, Portugal.
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