| Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis. | |
| | |
MedLine Citation:
|
PMID: 22223175 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Real-time tissue elastography (RTE), acoustic radiation force impulse (ARFI) imaging, and transient elastography (TE) are new technologies that are used for liver stiffness evaluation. The aim of this study was to compare these methods in the same population and to determine their diagnostic accuracy in the prediction of liver fibrosis. METHODS: Forty-five consecutive, previously biopsied, patients with chronic liver disease and 27 normal subjects underwent TE, RTE, and ARFI on the right liver lobe. Correlation coefficients between measurements, Metavir fibrosis stage, and histological necro-inflammatory activity (adjusted for fibrosis stage) were evaluated via Spearman's rank order correlation coefficients. Areas under the receiver operating characteristic curve (AUROCs) were calculated to predict each fibrosis stage. RESULTS: Failure or inconsistent results occurred in 12.5% of the attempts at TE, but in none of the attempts at RTE and ARFI. The three methods showed high correlation with fibrosis and poor correlation with necro-inflammatory activity. TE and ARFI exhibited high diagnostic accuracy (AUROCs ≥0.9) in diagnosing cirrhosis (F4 Metavir). All three methods presented fair (AUROCs >0.7) to good (AUROCs >0.8) diagnostic accuracy in diagnosing fibrosis (F1-4 Metavir) and significant fibrosis (F2-4 Metavir), with TE showing the best performance (AUROCs were 0.878 for fibrosis and 0.897 for significant fibrosis). CONCLUSIONS: TE and ARFI provide high diagnostic accuracy in the diagnosis of cirrhosis. When feasible, TE may perform better than RTE and ARFI in predicting fibrosis and significant fibrosis, but larger studies are needed. |
| | |
Authors:
|
Silvia Colombo; Marco Buonocore; Anna Del Poggio; Carlo Jamoletti; Stefano Elia; Mario Mattiello; Davide Zabbialini; Paolo Del Poggio |
Related Documents
:
|
19963585 - 4d ct image simulation using b-spline deformable model and cosine interpolation of defo... 11584235 - Performance evaluation of an automated system for registration and postprocessing of ct... 21819195 - Interobserver variability in the interpretation of computed tomography following aneury... 22065875 - A pilot study to evaluate 3'-deoxy-3'-18f-fluorothymidine pet for initial and early res... 8903075 - Medial temporal lobe heterotopia as a cause of increased hippocampal and amygdaloid mri... 22049965 - Intracapsular origin of the long head of the biceps tendon with glenoid avulsion of the... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
|
Title: Journal of gastroenterology Volume: - ISSN: 1435-5922 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Hepatology Unit, Treviglio Hospital, Piazza Ospedale n.1, 24047, Treviglio (Bergamo), Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glomerella truncata: Another Glomerella species with an atypical mating system.
Next Document: Risk factors of early re-bleeding and mortality in patients with ruptured gastric varices and concom...