Document Detail

Head-to-head comparison between delayed enhancement and percent infarct mapping for assessment of myocardial infarct size in a canine model.
MedLine Citation:
PMID:  19025946     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare a novel method, percent-infarct-mapping (PIM), with conventional delayed enhancement (DE) of contrast for accurate myocardial viability assessment. Contrary to signal intensity (SI), the longitudinal relaxation-rate enhancement (DeltaR1) is an intrinsic parameter linearly proportional to the concentration of contrast agent (CA). Determining DeltaR1 voxel-by-voxel, after administering an infarct-avid CA, allows determination of per-voxel percentage of infarcted tissue. The feasibility of generating PIM is demonstrated in canine reperfused infarction using an infarct-avid, persistent-CA (PCA), (Gd)(ABE-DTTA). PIM is compared to the DE method using Gd(DTPA), and both to triphenyltetrazolium chloride (TTC) staining histochemistry. MATERIALS AND METHODS: In six dogs, 48 hours following closed-chest, 180-minute coronary occlusion, DE imaging was carried out. PCA was administered immediately thereafter. Pixel-by-pixel R1 maps of the entire left ventricle (LV) were generated 48 hours after PCA using inversion-recovery with multiple inversion times. R1, DeltaR1, and percent-infarct values were calculated voxel-by-voxel. RESULTS: Significant correlations (P < 0.01, R >or= 0.8) were obtained for percent-infarct-per-slice (PIS) determined by DE or PIM vs. those from corresponding TTC-stained slices. Compared to TTC, DE overestimated PIS by 32 +/- 18%. PIM underestimated PIS by 2.5 +/- 4.9%. Infarction fraction overestimation was 29 +/- 6% of LV by DE, but only 1.0 +/- 2.3% by PIM. Errors with PIM were significantly smaller than those with DE. Infarct area determined by signal intensity was similarly overestimated whether using Gd(DTPA) or Gd(ABE-DTTA). CONCLUSION: The DeltaR1-based PIM method is highly reproducible and more accurate than DE for quantifying myocardial viability in vivo.
Balázs Ruzsics; Pál Surányi; Pál Kiss; Brigitta C Brott; Ada Elgavish; Tamas Simor; Gabriel A Elgavish
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  28     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1386-92     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
University of Alabama at Birmingham, Department of Biochemistry & Molecular Genetics MCLM 556, Birmingham, AL 35294-0005, USA.
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MeSH Terms
Analysis of Variance
Contrast Media
Disease Models, Animal
Gadolinium DTPA / diagnostic use*
Image Enhancement / methods*
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Myocardial Infarction / diagnosis*
Organometallic Compounds / diagnostic use*
Pentetic Acid / diagnostic use
Regression Analysis
Grant Support
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 0/gadolinium N-(2-butyryloxyethyl)-N'-(2-ethyloxyethyl)-N,N'-bis(N'',N''-bis(carboxymethyl)acetamido)-1,2-ethanediamine; 67-43-6/Pentetic Acid; 80529-93-7/Gadolinium DTPA

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