Document Detail


Head and neck squamous cell carcinoma is not associated with interleukin-18 promoter gene polymorphisms: a case-control study.
MedLine Citation:
PMID:  18940019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the association of two functional single nucleotide polymorphisms in the promoter region of the interleukin-18 gene, at positions -607 and -137, with head and neck squamous cell carcinoma. DESIGN: Genomic deoxyribonucleic acid was extracted, by the salting-out method, from peripheral blood leukocytes. Single nucleotide polymorphisms of the interleukin-18 gene at positions -607 (cytosine/adenine) and -137 (guanine/cytosine) were analysed by sequence-specific polymerase chain reaction. SUBJECTS: One hundred and eleven patients (86 men and 25 women; mean age 56.7+/-13.7 years) and 212 regional controls (165 men and 47 women; mean age 53.3+/-12.2 years) were studied. Control subjects comprised healthy volunteers or cancer-free individuals presenting with otolaryngological disease. The diagnosis of squamous cell carcinoma was confirmed histopathologically. Various clinical parameters were collected at diagnosis, including tumour site, tumour size, lymph node involvement, distant metastasis and stage. RESULTS: There was no significant association between the allele, genotype or haplotype frequencies of the two single nucleotide polymorphisms of the interleukin-18 promoter and the head and neck squamous cell carcinoma susceptibility or clinical parameters at diagnosis. CONCLUSION: Interleukin-18 polymorphisms at positions -607 and -137 did not confer susceptibility to head and neck squamous cell carcinoma in southern Iranian patients.
Authors:
V Asefi; Z Mojtahedi; B Khademi; S Naeimi; A Ghaderi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-22
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  123     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  444-8     Citation Subset:  AIM; IM    
Affiliation:
Division of ENT, Namazee Hospital, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alleles
Carcinoma, Squamous Cell / genetics*
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Head and Neck Neoplasms / genetics*
Humans
Interleukin-18 / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/Interleukin-18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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