Document Detail

Head and neck mucosal melanoma.
MedLine Citation:
PMID:  16317276     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this article is to discuss the optimal treatment and outcomes for head and neck mucosal melanoma. METHODS: Review the pertinent literature. RESULTS: Head and neck mucosal melanoma is a rare entity comprising less than 1% for all Western melanomas. It usually arises in the nasal cavity, paranasal sinuses, and oral cavity. The optimal treatment is surgery. The likelihood of local recurrence after resection is approximately 50%. Radiotherapy (RT) reduces the likelihood of local failure but probably does not enhance survival, which is primarily impacted by advanced T stage and the presence of regional metastases. The 5-year survival rates vary from approximately 20 to 50%. Although the median time to relapse is roughly 1 year or less, late failures are common and cause-specific survival continues to decline after 5 years. CONCLUSION: The optimal treatment is surgery. Postoperative RT improves local-regional control but may not impact survival. Definitive RT may occasionally cure patients with unresectable local-regional disease or at least provide long-term palliation.
William M Mendenhall; Robert J Amdur; Russell W Hinerman; John W Werning; Douglas B Villaret; Nancy Price Mendenhall
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  28     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-30     Citation Subset:  IM    
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
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MeSH Terms
Aged, 80 and over
Chemotherapy, Adjuvant
Combined Modality Therapy
Head and Neck Neoplasms / mortality,  pathology*,  radiotherapy,  surgery
Lymphatic Metastasis
Melanoma / mortality,  pathology*,  radiotherapy,  surgery
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / mortality,  pathology,  radiotherapy,  surgery,  therapy
Mucous Membrane / pathology*
Nasal Mucosa / pathology
Neoplasm Recurrence, Local
Neoplasm Staging
Nose Neoplasms / mortality,  pathology,  radiotherapy,  surgery,  therapy
Palatal Neoplasms / mortality,  pathology,  radiotherapy,  surgery,  therapy
Paranasal Sinus Neoplasms / mortality,  pathology,  radiotherapy,  surgery,  therapy
Radiotherapy, Adjuvant
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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