Document Detail


Head and neck manifestations of Wegener's granulomatosis.
MedLine Citation:
PMID:  17216737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wegener's Granulomatosis (WG) is a necrotizing granulomatous angiitis that presents the classic ELK triad of ear, nose, throat (E), lung (L), and kidney (K) involvement. Its potential rapid and fatal outcome makes the early recognition--before irreversible organ involvement occurs--mandatory. The aetiology is still unknown. Today, immunosuppressive therapy makes WG a treatable disease with a chronically relapsing course. The otorhinolaryngologist plays an important role in early diagnosis of WG, because in up to 95% of the patients initial WG symptoms are observed in the head and neck region. The majority of these patients show nasal or sinunasal involvement. Common manifestations are sinusitis, crusting of the nose, and development of saddle nose deformity. Other head and neck problems are middle and inner ear symptoms and subglottic stenosis. Follow up and activity assessment of the disease are also important roles to play for the otorhinolarygologist.
Authors:
S Gottschlich; P Ambrosch; D Kramkowski; M Laudien; T Buchelt; W L Gross; B Hellmich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rhinology     Volume:  44     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany. gottschlich@hno.uni-kiel.de
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Diagnosis, Differential
Endoscopy
Humans
Immunosuppressive Agents / therapeutic use
Otorhinolaryngologic Diseases / diagnosis*,  drug therapy,  immunology,  surgery
Prognosis
Recurrence
Wegener Granulomatosis / diagnosis*,  drug therapy,  immunology,  surgery
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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