| Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation. | |
| | |
MedLine Citation:
|
PMID: 21610469 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Novel noninvasive functional imaging methods are necessary to predict therapeutic outcome and thereby improve the ability to properly select patients for treatment with both conventional and targeted therapies, to better evaluate therapeutic effectiveness during the early phases of treatment, and to enhance a priori risk assessment for treatment induced toxicity. Functional metabolic imaging typically involves pretreatment baseline magnetic resonance imaging (MRI) and/or positron emission tomographic (PET) scans and performance of subsequent scans during and/or after treatment. Imaging parameter changes are routinely attributed to the intervening therapy and clinical outcomes subsequently correlated with these changes. The physiologic parameter(s) that best correlate with clinical outcome and the relative utility of MRI versus PET are unknown, however. Furthermore, tumor vascular physiology and metabolic parameters are heterogeneous and dynamic processes. Large daily fluctuations often occur in the absence of treatment. The magnitude of this temporal variability is not established for MRI or for PET. Routine and meaningful clinical application of functional imaging requires understanding and quantification of the intrinsic variability of the underlying biologic processes and a demonstration that treatment-induced changes exceed intrinsic temporal variation. |
| | |
Authors:
|
David M Brizel |
Related Documents
:
|
8517369 - Optimizing the diagnosis of hippocampal sclerosis using mr imaging. 8896629 - Reversible signal abnormalities in the hippocampus and neocortex after prolonged seizures. 15310029 - Zeta waves, an unusual eeg finding in structural brain lesions: report of two patients. 20116809 - Spectrum of epilepsy in wilson's disease with electroencephalographic, mr imaging and p... 16406729 - The role of fdg-pet, ictal spect, and meg in the epilepsy surgery evaluation. 15337129 - Early post-operative seizures after burr-hole drainage for chronic subdural hematoma: c... 7489699 - Hemimegalencephaly: localized proton magnetic resonance spectroscopy in vivo. 10966699 - Segmental wall thickening in the colonic loop distal to colonic carcinoma at ct: import... 14579399 - Right posterior hepatic notch sign: a simple diagnostic mr finding of cirrhosis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cancer journal (Sudbury, Mass.) Volume: 17 ISSN: 1540-336X ISO Abbreviation: Cancer J Publication Date: 2011 May-Jun |
Date Detail:
|
Created Date: 2011-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100931981 Medline TA: Cancer J Country: United States |
Other Details:
|
Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
|
From the Duke University Cancer Institute, Durham, NC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Image-guided positioning and tracking.
Next Document: Advances in treatment techniques: arc-based and other intensity modulated therapies.