| Head motion analysis during cognitive fMRI examination: application in patients with schizophrenia. | |
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MedLine Citation:
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PMID: 16005998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Functional MRI (fMRI) has become an important imaging modality for analyzing the neural mechanisms underlying schizophrenia. Earlier studies indicate that patients with schizophrenia tend to generate involuntary and unnecessary head motion during visual tasks. Since head motion can deteriorate the quality of fMRI data, an investigation was needed to examine the type and extent of head motion from patients with schizophrenia undergoing fMRI. METHODS: Patients with schizophrenia and demographically-matched healthy comparison subjects underwent fMRI examination involving visual working memory tasks. We obtained head movement parameters (three translational and three rotational) through mathematical realignment of the volumetric image data, and transformed these parameters into head displacement indices to quantify the subject's head motion in space. RESULTS: We found no group difference in displacement indices between the two groups. Group comparison of movement parameters indicated that the patient group showed reduced head motion along the superior-inferior direction when compared to healthy individuals. CONCLUSION: These results suggest that cognitive fMRI examination in patients with schizophrenia can be successfully conducted without the deteriorative effects of head motion. |
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Authors:
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Seung-Schik Yoo; Byung-Gil Choi; Rahyeong Juh; Chi-Un Pae; Chang-Uk Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience research Volume: 53 ISSN: 0168-0102 ISO Abbreviation: Neurosci. Res. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-01 Completed Date: 2005-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 84-90 Citation Subset: IM |
Affiliation:
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Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Mapping Case-Control Studies Cognition / physiology* Female Head / blood supply*, physiopathology Head Movements / physiology* Humans Image Processing, Computer-Assisted / methods Male Memory, Short-Term / physiology Neuropsychological Tests / statistics & numerical data Orthodontic Appliances, Functional* Oxygen / blood Schizophrenia / physiopathology* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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