| Head injury (moderate to severe). | |
| | |
MedLine Citation:
|
PMID: 21418686 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
INTRODUCTION: Head injury in young adults is often associated with motor vehicle accidents, violence, and sports injuries. In older adults it is often associated with falls. Severe head injury can lead to secondary brain damage from cerebral ischaemia resulting from hypotension, hypercapnia, and raised intracranial pressure. Severity of brain injury is assessed using the Glasgow Coma Scale (GCS). While about one quarter of people with severe brain injury (GCS score less than 8) will make a good recovery, about one third will die, and one fifth will have severe disability or be in a vegetative state. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of interventions to reduce complications of moderate to severe head injury as defined by Glasgow Coma Scale? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 17 systematic reviews, RCTs, or observational studies that met our inclusion criteria. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: antibiotics, anticonvulsants, corticosteroids, hyperventilation, hypothermia, and mannitol. |
| | |
Authors:
|
Ian Maconochie; Mark Ross |
Related Documents
:
|
12149716 - Mature teratoma arising in intraabdominal undescended testis in an infant with previous... 18947666 - Torsion of the spermatic cord after orchiopexy. 16680236 - Axial torsion and gangrene of a giant meckel's diverticulum. 317786 - Malformed genitalia in the 47,xyy genotype. 3747036 - A modified extra-anatomic route for revascularization of the lower extremity. 8385556 - Dermatofibrosarcoma protuberans of the hand: a case report. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-10 |
Journal Detail:
|
Title: Clinical evidence Volume: 2010 ISSN: 1752-8526 ISO Abbreviation: Clin Evid (Online) Publication Date: 2010 |
Date Detail:
|
Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101294314 Medline TA: Clin Evid (Online) Country: England |
Other Details:
|
Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
|
Department of Paediatric Accident and Emergency, St Mary's Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Warts (genital).
Next Document: Epilepsy (generalised).