Document Detail

Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children's Oncology Group study.
MedLine Citation:
PMID:  20217209     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A comprehensive case-control study was conducted to determine potential risk factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. This analysis evaluated possible associations between previous head injury and ionizing radiation exposure through diagnostic X-rays and medulloblastoma/PNET.
METHODS: Mothers of 318 cases <6 years of age at diagnosis between 1991 and 1997 and registered with the Children's Oncology Group were interviewed. Mothers of 318 matching controls were selected through random digit dialing and interviewed.
RESULTS: An association was not detected between previous head injury (OR: 0.78, 95% CI: 0.40-1.5) or head X-ray for any reason including head injury with medulloblastoma/PNET. A statistically non-significant excess of cases reported having an X-ray for reason other than head injury (OR 2.3, 95% CI 0.91-5.7). When cases that received an X-ray for a common symptom of medulloblastoma/PNET were considered unexposed this association weakened (OR: 1.3, 95% CI: 0.49-3.7). No dose-response relationship was observed.
CONCLUSIONS: Head injury and exposure to diagnostic head X-rays were not associated with medulloblastoma/PNET in this study. Future studies should investigate all imaging procedures with ionizing radiation exposure including computed tomography scans and utilize radiation dose estimations.
Saira Khan; Alison A Evans; Lucy Rorke-Adams; Manuela A Orjuela; Tania Shiminski-Maher; Greta R Bunin
Related Documents :
21970789 - Transfer of newborns to neonatal care unit: a registry based study in northern tanzania.
15031239 - Interventions for the prevention of falls in older adults: systematic review and meta-a...
16009979 - First-time inversion ankle ligament trauma: the effects of sex, level of competition, a...
9338829 - Factors affecting the severity of motor vehicle traffic crashes involving young drivers...
19425059 - Clinical and physiological assessments for elucidating falls risk in parkinson's disease.
20545629 - Recurrent falls and mortality in parkinson's disease: a prospective two-year follow-up ...
20056969 - Combined effect of resting heart rate and physical activity on ischaemic heart disease:...
25487669 - Risk factors for persistent proteinuria after a 2-year combination therapy for severe c...
23348399 - A nontargeted proteomic study of the influence of androgen excess on human visceral and...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-09
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  21     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1017-23     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / etiology*
Case-Control Studies
Cerebellar Neoplasms / etiology*
Child, Preschool
Craniocerebral Trauma / complications*
Medulloblastoma / etiology*
Neuroectodermal Tumors, Primitive / etiology*
Radiography / adverse effects
Risk Assessment / methods,  statistics & numerical data
Risk Factors
Grant Support
CA60951/CA/NCI NIH HHS; CA98543/CA/NCI NIH HHS; R01 CA060951-04/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA098543-08/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Closing the Research to Practice Gap in Children's Mental Health: Structures, Solutions, and Strateg...
Next Document:  Estimation of cancer incidence and mortality attributable to smoking in China.