| Head growth in cocaine-exposed infants: relationship to neonate hair level. | |
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MedLine Citation:
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PMID: 7790518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine brain growth retardation is the most common brain abnormality in infants of cocaine-abusing mothers. We report a cross-sectional study of "at-risk" pregnancies with 34 infants born to mothers urine positive for cocaine at delivery compared to 33 infants born to urine-negative mothers from the same clinic. Degree of cocaine exposure was assessed by radioimmunoassay of combined cocaine and benzoylecgonine (BE) levels in neonatal hair samples. Twenty-eight neonates were hair-positive for BE (mean 2507.40 +/- 1248.88 ng/g hair; range 716 to 5440 ng/g) and differed significantly from the control infants (n = 33) in head circumference and head growth percentiles. A negative correlation approaching significance was found between mean BE and head circumference (r = -.36; p < .06) in the group of newborns with hair positive for BE (n = 28). The study demonstrates for the first time head growth abnormalities in association with levels of cocaine exposure. |
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Authors:
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F R Sallee; L P Katikaneni; P D McArthur; H M Ibrahim; L Nesbitt; G Sethuraman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of developmental and behavioral pediatrics : JDBP Volume: 16 ISSN: 0196-206X ISO Abbreviation: J Dev Behav Pediatr Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-07-27 Completed Date: 1995-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006933 Medline TA: J Dev Behav Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: IM |
Affiliation:
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Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cocaine / analogs & derivatives, analysis* Cross-Sectional Studies Female Hair / chemistry* Head / abnormalities* Humans Infant, Newborn Male Maternal Behavior Narcotics Pregnancy Prenatal Exposure Delayed Effects* Substance-Related Disorders / complications*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 50-36-2/Cocaine; 519-09-5/benzoylecgonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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