Document Detail

Head growth in cocaine-exposed infants: relationship to neonate hair level.
MedLine Citation:
PMID:  7790518     Owner:  NLM     Status:  MEDLINE    
Intrauterine brain growth retardation is the most common brain abnormality in infants of cocaine-abusing mothers. We report a cross-sectional study of "at-risk" pregnancies with 34 infants born to mothers urine positive for cocaine at delivery compared to 33 infants born to urine-negative mothers from the same clinic. Degree of cocaine exposure was assessed by radioimmunoassay of combined cocaine and benzoylecgonine (BE) levels in neonatal hair samples. Twenty-eight neonates were hair-positive for BE (mean 2507.40 +/- 1248.88 ng/g hair; range 716 to 5440 ng/g) and differed significantly from the control infants (n = 33) in head circumference and head growth percentiles. A negative correlation approaching significance was found between mean BE and head circumference (r = -.36; p < .06) in the group of newborns with hair positive for BE (n = 28). The study demonstrates for the first time head growth abnormalities in association with levels of cocaine exposure.
F R Sallee; L P Katikaneni; P D McArthur; H M Ibrahim; L Nesbitt; G Sethuraman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  16     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA.
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MeSH Terms
Cocaine / analogs & derivatives,  analysis*
Cross-Sectional Studies
Hair / chemistry*
Head / abnormalities*
Infant, Newborn
Maternal Behavior
Prenatal Exposure Delayed Effects*
Substance-Related Disorders / complications*,  diagnosis
Reg. No./Substance:
0/Narcotics; 50-36-2/Cocaine; 519-09-5/benzoylecgonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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