| Head-down manoeuvre in patients with a high symptom score for orthostatic intolerance reveals impaired right brain frontal lobe vasoreactivity. | |
| | |
MedLine Citation:
|
PMID: 15978491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Autonomic nerve dysregulation produces a sense of impaired well-being and interferes with work performance in affected individuals. In this study, we characterized the pathophysiology of this condition. METHODS: Six patients with high symptom scores for orthostatic intolerance (OI) along with age- and sex-matched normal volunteers were directed to perform a head-down manoeuvre, and the change in cerebral blood flow (CBF) and cerebral oxygen levels (rSO(2)) in the right and left frontal lobes was measured using near-infrared spectroscopy (NIRS). RESULTS: The head-down manoeuvre induced a much greater increase in right-sided total haemoglobin concentration (THbl) in normal volunteers (0.51+/-0.24) when compared to symptomatic patients (0.0+/-0.04) but had no effect on left-sided THbl (P<0.05) in either group. Five of 6 patients showed a gradual decrease in right-sided THbl when assuming a sitting position, and all patients with this pattern complained of symptoms of multiple autonomic dysfunction. Further, this pattern of changes in right-sided THbl was not observed in normal volunteers. CONCLUSIONS: The gradual decrease of THbl with the sitting position and the lack of increase during the head-down manoeuvre in symptomatic patients suggest that these patients have impaired vasoreactivity in the right frontal lobes. SIGNIFICANCE: This impaired vasoreactivity likely reflects dysfunction of the right hemisphere and the sympathetic nervous system in patients with OI. |
| | |
Authors:
|
Nobusada Shinoura; Ryozi Yamada |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2005-03-26 |
Journal Detail:
|
Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 116 ISSN: 1388-2457 ISO Abbreviation: Clin Neurophysiol Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-06-27 Completed Date: 2005-08-09 Revised Date: 2008-09-10 |
Medline Journal Info:
|
Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1286-90 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Komagome Metropolitan Hospital, 3-18-22 Hon-Komagome, Bunkyo-ku, Tokyo 113-8677, Japan. shinoura@cick.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Autonomic Nervous System Diseases / physiopathology* Case-Control Studies Cerebrovascular Circulation / physiology* Female Frontal Lobe / physiopathology* Functional Laterality / physiology Head-Down Tilt / physiology* Hemoglobins / metabolism Humans Hypotension, Orthostatic / physiopathology* Male Oxygen / blood Spectroscopy, Near-Infrared / methods |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Decreased vasoreactivity to right cerebral hemisphere pressure in migraine without aura: a near-infr...
Next Document: Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy...