Document Detail


Head direction cells and episodic spatial information in rats without a hippocampus.
MedLine Citation:
PMID:  9207146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To successfully navigate through the environment animals rely on information concerning their directional heading and location. Many cells within the postsubiculum and anterior thalamus discharge as a function of the animal's head direction (HD), while many cells in the hippocampus discharge in relation to the animal's location. We placed lesions in the hippocampus and recorded from HD cells in the postsubiculum and anterior thalamus. Lesions of the hippocampus did not disrupt the HD cell signal in either brain area, indicating that the HD cell signal must be generated by structures external to the hippocampus. In addition, each cell's preferred firing direction remained stable across days when the lesioned animal was placed into a novel environment. This stability appeared to weaken after several weeks of nonexposure to the new enclosure for two out of five animals, and subsequently recorded cells from these two animals established a new angular relationship between the familiar and novel environments. Our results suggest that extra-hippocampal structures are capable of creating and maintaining a novel representation of the animal's environmental context. This representation shares features in common with mnemonic processes involving episodic memory that until now were assumed to require an intact hippocampus.
Authors:
E J Golob; J S Taube
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  94     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-05     Completed Date:  1997-08-05     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7645-50     Citation Subset:  IM    
Affiliation:
Department of Psychology, 6207 Gerry Hall, Dartmouth College, Hanover, NH 03755, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Hippocampus / injuries,  pathology,  physiology*
Rats
Spatial Behavior / physiology*
Thalamus / pathology,  physiology
Grant Support
ID/Acronym/Agency:
MH01286/MH/NIMH NIH HHS; MH48924/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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