Document Detail

Head cooling for neonatal encephalopathy: the state of the art.
MedLine Citation:
PMID:  17762415     Owner:  NLM     Status:  MEDLINE    
The possibility that hypothermia started during or after resuscitation at birth might reduce brain damage and cerebral palsy has tantalized clinicians for a long time. The key insight was that transient severe hypoxia-ischemia can precipitate a complex biochemical cascade leading to delayed neuronal loss. There is now strong experimental and clinical evidence that mild to moderate cooling can interrupt this cascade, and improve the number of infants surviving without disability in the medium term. The key remaining issues are to finding better ways of identifying babies who are most likely to benefit, to define the optimal mode and conditions of hypothermia and to find ways to further improve the effectiveness of treatment.
Alistair Jan Gunn; Peter D Gluckman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  50     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  636-51     Citation Subset:  IM    
Department of Physiology, The University of Auckland, Auckland, New Zealand.
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MeSH Terms
Age Factors
Body Temperature
Hypothermia, Induced / adverse effects,  methods*
Hypoxia-Ischemia, Brain / metabolism,  physiopathology,  therapy*
Infant, Newborn
Patient Selection
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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