Document Detail


Head circumferences in twins with and without Autism Spectrum Disorders.
MedLine Citation:
PMID:  23321801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs.
Authors:
Wendy Froehlich; Sue Cleveland; Andrea Torres; Jennifer Phillips; Brianne Cohen; Tiffany Torigoe; Janet Miller; Angie Fedele; Jack Collins; Karen Smith; Linda Lotspeich; Lisa A Croen; Sally Ozonoff; Clara Lajonchere; Judith K Grether; Joachim Hallmayer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  43     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-16     Completed Date:  2014-03-20     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2026-37     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Cephalometry*
Child
Child Development Disorders, Pervasive / complications,  genetics*
Child, Preschool
Diseases in Twins / genetics*
Female
Head / pathology*
Humans
Macrocephaly / complications,  diagnosis*,  genetics
Male
Twins / genetics*
Grant Support
ID/Acronym/Agency:
R01 MH067005/MH/NIMH NIH HHS; R01MH067005/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Progressive Clustering Based Method for Protein Function Prediction.
Next Document:  Residual difficulties with categorical induction in children with a history of autism.