| Head Circumferences in Twins With and Without Autism Spectrum Disorders. | |
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MedLine Citation:
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PMID: 23321801 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. |
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Authors:
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Wendy Froehlich; Sue Cleveland; Andrea Torres; Jennifer Phillips; Brianne Cohen; Tiffany Torigoe; Janet Miller; Angie Fedele; Jack Collins; Karen Smith; Linda Lotspeich; Lisa A Croen; Sally Ozonoff; Clara Lajonchere; Judith K Grether; Joachim Hallmayer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: - ISSN: 1573-3432 ISO Abbreviation: J Autism Dev Disord Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Child and Adolescent Psychiatry, Department of Psychiatry, School of Medicine, Stanford University, 401 Quarry Road, MC 5719, Stanford, CA, 94305, USA, wendyf@stanford.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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