Document Detail

HeLa cells have histamine H1-receptors which mediate activation of the K+ conductance.
MedLine Citation:
PMID:  2581624     Owner:  NLM     Status:  MEDLINE    
HeLa cells responded to exogenous histamine with a transient hyperpolarization due to increased membrane conductance to K+. After successive applications of histamine, the cell membrane became virtually unresponsive (desensitized). The responses were blocked by pyrilamine but not by cimetidine. Thus, it appears that HeLa cells have H1-receptors which mediate an increase in the K+ conductance.
A Hazama; T Yada; Y Okada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  845     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-24     Completed Date:  1985-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / physiology
Cimetidine / pharmacology
Electric Conductivity
Electric Stimulation
Hela Cells / drug effects,  physiology*
Histamine / pharmacology
Ion Channels / drug effects,  physiology*
Membrane Potentials / drug effects
Potassium / metabolism*
Pyrilamine / pharmacology
Quinine / pharmacology
Receptors, Histamine / physiology*
Receptors, Histamine H1 / physiology*
Reg. No./Substance:
0/Ion Channels; 0/Receptors, Histamine; 0/Receptors, Histamine H1; 130-95-0/Quinine; 51-45-6/Histamine; 51481-61-9/Cimetidine; 7440-09-7/Potassium; 91-84-9/Pyrilamine

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