Document Detail

HbSC hemoglobinopathy suspected by chest x-ray and red blood cell morphology.
MedLine Citation:
PMID:  16502600     Owner:  NLM     Status:  MEDLINE    
Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a significant proportion of hyperchromic RBC, corresponding to secondary, non hereditary spherocytosis, presence of numerous target cells and occasional HbC crystals on Pappenheim stained blood films. The diagnosis of HbSC disease was confirmed by HPLC, iso-electric focusing and citrate agar electrophoresis of hemoglobin and by reverse phase HPLC of globin-chains. This case illustrates the importance of screening for hemoglobin anomalies as it is performed in a multiethnic country such as the Grand Duchy of Luxembourg
J Thoma; D Kutter; S Casel; P Rosoux; C Braas; F Ries; P Groff; G Kalmes; B Golinska
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  60     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-04-11     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
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MeSH Terms
Erythrocytes / pathology*
Hemoglobin SC Disease / pathology*,  radiography*
Thoracic Vertebrae / radiography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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