Document Detail


HbOThrace trait, HbOThrace hemoglobinopathy and HbOThrace/Hb beta zero hemoglobinopathy: a retrospective study of 118 cases.
MedLine Citation:
PMID:  10205993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HbOThrace is an abnormal hemoglobin which is constructed by defective beta chains (Glu121-->Lys121). It mostly characterises the Muslim minority of the Thrace region. During the last 6 years, our department detected HbOThrace in 118 cases. Four groups were formed, the first consisted of cases of HbOThrace trait with normal iron and ferritin levels, the second of cases of HbOThrace hemoglobinopathy, the third of cases of HbOThrace/Hb beta zero hemoglobinopathy and the fourth of cases of HbOThrace trait with low iron and ferritin levels. The second, third and fourth group were compared with the first one. The conclusion is that the presence of HbOThrace leads to a mild hypochromic anemia, with no clinical findings, but the coexistence of beta zero gene or iron deficiency produces more pronounced laboratory findings and even clinically evident anemia.
Authors:
D Vassiliadou; V Papadopoulos; C Konstantinidou; M Arnaoutoglou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia medica     Volume:  40     ISSN:  0204-8043     ISO Abbreviation:  Folia Med (Plovdiv)     Publication Date:  1998  
Date Detail:
Created Date:  1999-05-26     Completed Date:  1999-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984761R     Medline TA:  Folia Med (Plovdiv)     Country:  BULGARIA    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Affiliation:
Department of Hematology, Xanthi General Hospital, Greece.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hypochromic / blood,  complications,  genetics
Anemia, Iron-Deficiency / blood,  complications,  genetics
Ferritins / blood
Hemoglobinopathies / blood,  complications,  genetics*
Hemoglobins, Abnormal / chemistry,  genetics*
Heterozygote
Homozygote
Humans
Iron / blood,  deficiency
Point Mutation
beta-Thalassemia / blood,  complications,  genetics
Chemical
Reg. No./Substance:
0/Hemoglobins, Abnormal; 7439-89-6/Iron; 9007-73-2/Ferritins

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