| HbOThrace trait, HbOThrace hemoglobinopathy and HbOThrace/Hb beta zero hemoglobinopathy: a retrospective study of 118 cases. | |
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MedLine Citation:
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PMID: 10205993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HbOThrace is an abnormal hemoglobin which is constructed by defective beta chains (Glu121-->Lys121). It mostly characterises the Muslim minority of the Thrace region. During the last 6 years, our department detected HbOThrace in 118 cases. Four groups were formed, the first consisted of cases of HbOThrace trait with normal iron and ferritin levels, the second of cases of HbOThrace hemoglobinopathy, the third of cases of HbOThrace/Hb beta zero hemoglobinopathy and the fourth of cases of HbOThrace trait with low iron and ferritin levels. The second, third and fourth group were compared with the first one. The conclusion is that the presence of HbOThrace leads to a mild hypochromic anemia, with no clinical findings, but the coexistence of beta zero gene or iron deficiency produces more pronounced laboratory findings and even clinically evident anemia. |
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Authors:
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D Vassiliadou; V Papadopoulos; C Konstantinidou; M Arnaoutoglou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia medica Volume: 40 ISSN: 0204-8043 ISO Abbreviation: Folia Med (Plovdiv) Publication Date: 1998 |
Date Detail:
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Created Date: 1999-05-26 Completed Date: 1999-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984761R Medline TA: Folia Med (Plovdiv) Country: BULGARIA |
Other Details:
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Languages: eng Pagination: 46-50 Citation Subset: IM |
Affiliation:
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Department of Hematology, Xanthi General Hospital, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hypochromic
/
blood,
complications,
genetics Anemia, Iron-Deficiency / blood, complications, genetics Ferritins / blood Hemoglobinopathies / blood, complications, genetics* Hemoglobins, Abnormal / chemistry, genetics* Heterozygote Homozygote Humans Iron / blood, deficiency Point Mutation beta-Thalassemia / blood, complications, genetics |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins, Abnormal; 7439-89-6/Iron; 9007-73-2/Ferritins |
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