Document Detail


HbE genotypes and fertility: a study on a Tibeto-Burmese population in Upper Assam, India.
MedLine Citation:
PMID:  18654872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The north-eastern states of India in general and the state of Assam in particular appear to be areas with a very high incidence of HbE, with the highest frequency of the allele observed among the Kachari population.
AIM: In the present study a Tibeto-Burmese speaking population of Assam, India has been studied with regard to haemoglobin E (HbE) and to examine the role of different HbE genotypes on fertility.
SUBJECTS AND METHODS: Detailed reproductive histories and socio-economic data were collected from 159 unrelated Mishing (a Tibeto-Burmese population) couples initially. Haemoglobin typing was done by restriction digestion to detect wild type (HbA/HbA), heterozygotes (HbA/HbE) and homozygotes (HbE/HbE).
RESULTS AND CONCLUSION: The HbE gene frequency for the total 318 individuals was 0.4623. The results suggest that HbE homozygosity is associated with a higher pregnancy rate. Mothers homozygous for HbE also have more live births in spite of having more spontaneous abortions. The study shows that HbE homozygous women may be getting an advantage up to the point of conception but beyond that various factors come into play to increase miscarriage and infant mortality and that the socio-economic factor is one important reason behind this.
Authors:
Bhaskar Das; Sarthak Sengupta
Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Annals of human biology     Volume:  35     ISSN:  1464-5033     ISO Abbreviation:  Ann. Hum. Biol.     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-09-17     Revised Date:  2011-05-10    
Medline Journal Info:
Nlm Unique ID:  0404024     Medline TA:  Ann Hum Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-31     Citation Subset:  IM    
Affiliation:
Department of Anthropology, University of Dibrugarh, Dibrugarh, 786 004 Assam, India. bd_das2002@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
DNA Primers
Demography
Female
Fertility / genetics*
Geography
Hemoglobin E / genetics*
Humans
India
Infant
Infant Mortality
Language
Male
Myanmar
Nuclear Family
Pregnancy
Tibet
Chemical
Reg. No./Substance:
0/DNA Primers; 9034-61-1/Hemoglobin E
Comments/Corrections
Retraction In:
Ann Hum Biol. 2011 May;38(3):382   [PMID:  21322769 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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