| HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. | |
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MedLine Citation:
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PMID: 21474403 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To determine the glycosylated haemoglobin (HbA(1c)) cut-points for diabetes and impaired fasting glucose (IFG) among Asian Indians. METHODS: Participants (n=525) were a random sample selected from the India Health Study. Based on history and fasting plasma glucose (FPG), participants were classified into known diabetes, newly diagnosed diabetes (NDD), impaired fasting glucose (IFG) [ADA and WHO criteria] or normal fasting glucose (NFG). Receiver Operating Characteristic curves were used to identify the optimum sensitivity and specificity for defining HbA(1c) cut-points for NDD and IFG against the FPG criteria. RESULTS: There were 64 participants with a known history of diabetes. Of the remaining 461, IFG was present in 44.7% (ADA) and 18.2% (WHO), and 10.4% were NDD. Mean HbA(1c) were 5.4 (±0.04)% for NFG; 5.7 (±0.06)% among IFG-ADA, 5.8 (±0.09)% among IFG-WHO; 7.5 (±0.33)% for NDD and 8.4 (±0.32)% for known diabetes. Optimal HbA(1c) cut-point for NDD was 5.8% (sensitivity=75%, specificity=75.5%, AUC=0.819). Cut-point for IFG (ADA) was 5.5% (sensitivity=59.7%, specificity=59.9%, AUC=0.628) and for IFG (WHO) was 5.6% (sensitivity=60.7%, specificity=65.1%, AUC=0.671). CONCLUSION: In this study population from north and south regions of India, the HbA(1c) cut-point that defines NDD (≥5.8%) was much lower than that proposed by an international expert committee and the American Diabetes Association (≥6.5%). A cut-point of ≥5.5% or ≥5.6% defined IFG, and was slightly lower than the ≥5.7% for high risk proposed, but accuracy was less than 70%. |
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Authors:
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Manisha Nair; Dorairaj Prabhakaran; K M Venkat Narayan; Rashmi Sinha; Ramakrishnan Lakshmy; Niveditha Devasenapathy; Carrie R Daniel; Ruby Gupta; Preethi S George; Aleyamma Mathew; Nikhil Tandon; K Srinath Reddy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: Primary care diabetes Volume: - ISSN: 1751-9918 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Primary Care Diabetes Europe. All rights reserved. |
Affiliation:
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Fogarty International Centre & Centre of Excellence-Centre for cArdiometabolic Risk Reduction in South Asia, Public Health Foundation of India, New Delhi 122002, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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