Document Detail


HbA1c in pregnancy.
MedLine Citation:
PMID:  23014257     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During pregnancy, the glucose levels vary according to the hormonal changes and the metabolic needs necessary to maintain fetal nutrition but strict glycemic control is essential to minimize the maternal and fetal morbidity and mortality of pregnancies complicated by diabetes. Although considered the "gold standard" for diagnosis, measurement of glucose in the blood is subject to several limitations, many of which are not widely appreciated. Measurement of A1c for diagnosis is appealing as with one number, a total, integrated view of glycemia over time is derived though it has some inherent limitations. Thus, supplementation with HbA1c, as is common outside pregnancy, seems appropriate. Before pregnancy, the target for metabolic control in women with diabetes is HbA1c values near the normal range. However, the upper normal range of HbA1c during normal pregnancy is only sparsely investigated with different methods though recently a number of papers have been published regarding the determination of reference ranges for HbA1c in pregnancy. These changes may have clinical implications for the assessment and management of glycemic control in diabetic pregnancy and calls for establishment of separate reference limits of HbA1c levels in different trimesters as compared to general population.
Authors:
Dalia Rafat; Jamal Ahmad
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Publication Detail:
Type:  Journal Article     Date:  2012-06-30
Journal Detail:
Title:  Diabetes & metabolic syndrome     Volume:  6     ISSN:  1878-0334     ISO Abbreviation:  Diabetes Metab Syndr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101462250     Medline TA:  Diabetes Metab Syndr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh 202002, India.
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