Document Detail

Hb SE disease: a clinico-hematological profile.
MedLine Citation:
PMID:  15947927     Owner:  NLM     Status:  MEDLINE    
Hb S and Hb E are globally common hemoglobinopathies. However, Hb SE double heterozygous state is uncommon, with only 25 cases reported so far in literature. We present two more cases. One presented with gallstones, and the other was asymptomatic. This type of disorder was previously described as a relatively asymptomatic condition compared to HbSS. A review of the 25 reported cases in literature shows that 40.7% (11/27) of these cases are symptomatic. Gender, hematological parameters and levels of Hb S, E or F do not predict clinical severity.
Pravas Mishra; H P Pati; Tathagat Chatterjee; Ashish Dixit; Dharma R Choudhary; M Upendra Srinivas; Manoranjan Mahapatra; V P Choudhry
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-06-10
Journal Detail:
Title:  Annals of hematology     Volume:  84     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2005-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
Department of Hematology, All-India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Anemia, Sickle Cell* / blood,  complications,  genetics
Gallstones / blood,  etiology,  genetics
Hemoglobin E* / analysis,  genetics
Hemoglobin, Sickle* / analysis,  genetics
Hemoglobinuria* / blood,  complications,  genetics
Severity of Illness Index
Reg. No./Substance:
0/Hemoglobin, Sickle; 9034-61-1/Hemoglobin E

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