Document Detail

Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions.
MedLine Citation:
PMID:  18560303     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Hazelnut allergy can vary between mild oral symptoms and potentially dangerous anaphylaxis. There is a need to predict which subjects are at risk for severe reactions. In this study, possibilities for 'component-resolved diagnosis', based on sensitization to different allergens in hazelnut, are discussed.
RECENT FINDINGS: One type of hazelnut allergy can be associated with sensitization to homologues of pollen allergens, predominantly birch, in hazelnut: Cor a 1 (Bet v 1) and Cor a 2 (profilin). These allergens account for relatively mild symptoms. However, subjects can also be sensitized to several other allergens in hazelnut that are related to more severe symptoms. These allergens are homologues of allergens in other nuts and peanut: Cor a 8 (lipid transfer protein) and Cor a 9 (11S globulin) and perhaps Cor a 11 (7S globulin). The clinical relevance of these and other potential hazelnut allergens has to be further defined. The diagnosis of hazelnut has to be confirmed by oral double-blind placebo-controlled food challenge.
SUMMARY: Sensitization to hazelnut can either be associated with mild oral symptoms, depending on sensitization to pollen, or with more serious allergic symptoms, related to sensitization to homologues of nut and peanut allergens.
Annebeth E Flinterman; Jaap H Akkerdaas; André C Knulst; Ronald van Ree; Suzanne G Pasmans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  8     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-08-14     Revised Date:  2011-06-21    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Anaphylaxis / diagnosis,  etiology,  immunology,  physiopathology*
Antigens, Plant / immunology,  metabolism,  therapeutic use
Corylus* / adverse effects
Desensitization, Immunologic / trends
Diagnosis, Differential
Molecular Mimicry
Nut Hypersensitivity / diagnosis,  immunology,  physiopathology*,  therapy
Pollen* / adverse effects
Severity of Illness Index
Structural Homology, Protein
Reg. No./Substance:
0/Antigens, Plant

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