Document Detail

Hazards of pentazocine for neonatal analgesia: a single-centre experience over 10 years.
MedLine Citation:
PMID:  18727849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In developing countries, neonatal analgesia for surgical procedures is a major challenge where postoperative care is inadequate. AIM: To report experience of pentazocine for neonatal surgery in a Nigerian tertiary hospital. METHODS: A retrospective study of surgical neonates who received pentazocine at the University of Benin Teaching Hospital in Benin City between January 1998 and December 2007. RESULTS: During the period, 2590 paediatric operations were performed including 368 (14.2%) neonates, 49 (13.3%) of whom had pentazocine. The other neonates received a variety of analgesics. Of 56 neonates who developed respiratory depression, 40 (71.4%) had pentazocine (p<0.0001). Fifteen (30.6%) neonates aged between 9 hours and 28 days [mean (SD) 12 (1.2) days] died between 1 and 36 hours following 8-hourly administration of 0.5 mg/kg pentazocine. In older children who had pentazocine, over-sedation was also a problem but there were no deaths. Deaths in neonates were mainly owing to persistent respiratory depression which was compounded by the unavailability of a paediatric ventilator. However, many neonates responded to naloxone. All neonates who died had an autopsy and no lesion was found which could have compromised respiratory function. CONCLUSION: The use of pentazocine in neonates was associated with high morbidity and mortality. Caution is required when using pentazocine for neonatal analgesia where post-operative respiratory support is insufficient.
O D Osifo; S E Aghahowa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  28     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Paediatric Surgery Unit, Department of Surgery, University of Benin Teaching Hospital, Benin City, Nigeria.
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MeSH Terms
Analgesia / adverse effects*,  methods
Analgesics, Opioid / adverse effects*
Developing Countries
Infant, Newborn
Pain, Postoperative / prevention & control*
Pentazocine / adverse effects*
Postoperative Complications
Respiratory Insufficiency / chemically induced
Retrospective Studies
Reg. No./Substance:
0/Analgesics, Opioid; 359-83-1/Pentazocine

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