| Hazards of pentazocine for neonatal analgesia: a single-centre experience over 10 years. | |
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MedLine Citation:
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PMID: 18727849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In developing countries, neonatal analgesia for surgical procedures is a major challenge where postoperative care is inadequate. AIM: To report experience of pentazocine for neonatal surgery in a Nigerian tertiary hospital. METHODS: A retrospective study of surgical neonates who received pentazocine at the University of Benin Teaching Hospital in Benin City between January 1998 and December 2007. RESULTS: During the period, 2590 paediatric operations were performed including 368 (14.2%) neonates, 49 (13.3%) of whom had pentazocine. The other neonates received a variety of analgesics. Of 56 neonates who developed respiratory depression, 40 (71.4%) had pentazocine (p<0.0001). Fifteen (30.6%) neonates aged between 9 hours and 28 days [mean (SD) 12 (1.2) days] died between 1 and 36 hours following 8-hourly administration of 0.5 mg/kg pentazocine. In older children who had pentazocine, over-sedation was also a problem but there were no deaths. Deaths in neonates were mainly owing to persistent respiratory depression which was compounded by the unavailability of a paediatric ventilator. However, many neonates responded to naloxone. All neonates who died had an autopsy and no lesion was found which could have compromised respiratory function. CONCLUSION: The use of pentazocine in neonates was associated with high morbidity and mortality. Caution is required when using pentazocine for neonatal analgesia where post-operative respiratory support is insufficient. |
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Authors:
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O D Osifo; S E Aghahowa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of tropical paediatrics Volume: 28 ISSN: 0272-4936 ISO Abbreviation: Ann Trop Paediatr Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2009-03-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8210625 Medline TA: Ann Trop Paediatr Country: England |
Other Details:
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Languages: eng Pagination: 205-10 Citation Subset: IM |
Affiliation:
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Paediatric Surgery Unit, Department of Surgery, University of Benin Teaching Hospital, Benin City, Nigeria. Leadekso@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia
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adverse effects*,
methods Analgesics, Opioid / adverse effects* Developing Countries Female Humans Infant, Newborn Male Nigeria Pain, Postoperative / prevention & control* Pentazocine / adverse effects* Postoperative Complications Respiratory Insufficiency / chemically induced Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 359-83-1/Pentazocine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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