Document Detail

Hazards of epinephrine in transsphenoidal pituitary surgery.
MedLine Citation:
PMID:  11773822     Owner:  NLM     Status:  MEDLINE    
A 79-year-old woman with no history of myocardial ischemia presented with symptoms of pituitary apoplexy for which an urgent transsphenoidal resection of the pituitary gland was undertaken. The nasal passages were prepared with topical application of epinephrine followed by injection of what was presumed to be 1% lidocaine containing 10 microg/ml(-1) of epinephrine. After only 1.5 mL of the solution had been injected, she developed a hypertensive crisis, which was immediately treated. Postoperatively, she developed a myocardial infarction. The risks associated with the use of vasopressors are reviewed and suggestions for their safe use are presented.
Y Rubuen Chelliah; Pirjo H Manninen
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  14     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-04     Completed Date:  2002-01-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Adjuvants, Anesthesia / administration & dosage,  adverse effects
Administration, Intranasal
Anesthetics, Local / administration & dosage
Emergency Treatment
Epinephrine / administration & dosage,  adverse effects*
Hypertension / chemically induced*
Intraoperative Complications*
Lidocaine / administration & dosage
Myocardial Infarction / chemically induced,  etiology
Pituitary Apoplexy
Postoperative Complications
Sphenoid Bone / surgery*
Vasoconstrictor Agents / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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