| Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. | |
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MedLine Citation:
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PMID: 19789403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Hawthorn's efficacy when added to contemporary evidence-based heart failure therapy is unknown. We aimed to determine whether hawthorn increases submaximal exercise capacity when added to standard medical therapy. METHODS AND RESULTS: We performed a randomized, double-blind, placebo-controlled trial in 120 ambulatory patients aged > or = 18 years with New York Heart Association (NYHA) class II-III chronic heart failure. All patients received conventional medical therapy, as tolerated, and were randomized to either hawthorn 450 mg twice daily or placebo for 6 months. The primary outcome was change in 6 min walk distance at 6 months. Secondary outcomes included quality of life (QOL) measures, peak oxygen consumption, and anaerobic threshold during maximal treadmill exercise testing, NYHA classification, left ventricular ejection fraction (LVEF), neurohormones, and measures of oxidative stress and inflammation. There were no significant differences between groups in the change in 6 min walk distance (P = 0.61), or on measures of QOL, functional capacity, neurohormones, oxidative stress, or inflammation. A modest difference in LVEF favoured hawthorn (P = 0.04). There were significantly more adverse events reported in the hawthorn group (P = 0.02), although most were non-cardiac. CONCLUSION: Hawthorn provides no symptomatic or functional benefit when given with standard medical therapy to patients with heart failure. This trial is registered in ClinicalTrials.gov ID: NCT00343902. |
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Authors:
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Suzanna M Zick; Bonnie Motyka Vautaw; Brenda Gillespie; Keith D Aaronson |
Related Documents
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1886473 - Exercise training in patients with impaired left ventricular function. 3192843 - Effect of dichloroacetate on the exercise performance of patients with heart failure. 8839323 - Interpersonal deficits and time spent in exercise or active recreation. |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: European journal of heart failure Volume: 11 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2010-01-11 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 990-9 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, University of Michigan, Ann Arbor, MI 48109-0708, USA. szick@umich.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00343902 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anaerobic Threshold / drug effects Chronic Disease Crataegus* Double-Blind Method Exercise Tolerance / drug effects* Female Follow-Up Studies Heart Failure / diagnosis, drug therapy*, mortality Humans Male Middle Aged Oxygen Consumption / drug effects, physiology Phytotherapy / methods* Plant Preparations / therapeutic use* Probability Quality of Life Reference Values Risk Assessment Severity of Illness Index Stroke Volume / drug effects Survival Rate Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00042/RR/NCRR NIH HHS; P50 HL 061202 01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Plant Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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