| Have we reached the point for in vivo rejuvenation? | |
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MedLine Citation:
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PMID: 18442329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stem cells are the major factor ensuring mammalian regeneration. Cell replacement therapy is an attempt to follow this natural process. Another strategy suggests a controlled de-differentiation of somatic cells to a stem-like state with subsequent re-differentiation. Indeed, the cultured mammalian somatic cells may be reprogrammed to a pluripotent state by the induction of a specific set of genes. The next logical step toward the goal of organism rejuvenation is to test the possibility of inducing the pluripotent state in somatic cells in vivo. Such an approach has the potential to improve upon and overcome several obstacles facing today's cell replacement therapy. |
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Authors:
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Amir Abramovich; Khachik K Muradian; Vadim E Fraifeld |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rejuvenation research Volume: 11 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-29 Completed Date: 2008-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 489-92 Citation Subset: IM |
Affiliation:
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The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Pluripotent Stem Cells / cytology Rejuvenation / physiology* Tissue Therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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