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Have We New Therapeutic Strategies in the Treatment of Renovascular Nephropathy?
MedLine Citation:
PMID:  22724464     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Renal artery stenosis (RAS) is a cause of hypertension and ischemic nephropathy. The incidence of this disorder is probably less than 1% in patients with mild hypertension, but rises to as high as 10 to 40% in patients with acute, severe or refractory hypertension. Significant RAS can be caused by atheromatous plaques, or due to fibromuscular dysplasia (FMD). Atherosclerotic lesions are present in almost 7% of adults older than 65 years and up to 50% of patients presenting with diffuse atherosclerotic disease. In contrast to atherosclerosis, FMD most often affects women under the age of 50 and typically involves the distal main renal artery or the intrarenal branches. The optimal treatment for RAS is not yet established. Based on recent trials, we reviewed the literature on pharmacological and endovascular treatment of atherosclerotic RAS and ischemic nephropathy.
Authors:
Rosario Cianci; Alessandro Zuccalà; Gaetano Lucisano; Biagio Barbano; Paola Martina; Antonietta Gigante; Gianfranco Clemenzia; Giorgio Fuiano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Current vascular pharmacology     Volume:  -     ISSN:  1875-6212     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Nephrology, �Sapienza� University of Rome, Viale del Policlinico 155, Rome, Italy. biagionet@hotmail.com.
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