| Have the renin-angiotensin-aldosterone system perturbations in cardiovascular disease been exhausted? | |
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MedLine Citation:
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PMID: 20827517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin-aldosterone system (RAAS) plays an important role in blood pressure control and volume homeostasis. Inappropriate activation of the RAAS has been implicated in the pathogenesis of hypertension and related cardiovascular disease. Several classes of agents that block RAAS signaling have been shown to be effective antihypertensives and to have cardioprotective and renoprotective properties. Because blockade of the RAAS is incomplete with any of the currently available monotherapies, combinations of these agents have been tested and shown to provide additional clinical benefit in patients with hypertension and various forms of cardiovascular and renal disease. |
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Authors:
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Sulaf J Mansur; Fadi G Hage; Suzanne Oparil |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 12 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 450-63 Citation Subset: IM |
Affiliation:
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Jefferson Clinic PC, Birmingham, AL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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pharmacology,
therapeutic use Angiotensin-Converting Enzyme Inhibitors / pharmacology, therapeutic use Antihypertensive Agents / pharmacology, therapeutic use Cardiovascular Diseases / drug therapy*, etiology, physiopathology Heart Failure / drug therapy, etiology, physiopathology Humans Hypertension / drug therapy, etiology, physiopathology Kidney Failure, Chronic / drug therapy, etiology, physiopathology Receptors, Mineralocorticoid / antagonists & inhibitors Renin / antagonists & inhibitors, drug effects, physiology Renin-Angiotensin System / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Receptors, Mineralocorticoid; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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