Document Detail

Hashimoto thyroiditis coexistent with papillary thyroid carcinoma.
MedLine Citation:
PMID:  16468540     Owner:  NLM     Status:  MEDLINE    
Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating a possible correlation between the two diseases. We studied a group of 89 subjects undergoing surgery for thyroid carcinomas compared with a control group of 89 subjects operated on for normofunctioning goiter, and a second group of 47 patients undergoing total thyroidectomy for HT. Association with HT was found in 19 of the 71 PTC subjects (26.7%) and in 8 goiter patients (8.9%), which was a significant difference (P < 0.02). Thirteen of the HT patients, mostly with the nodular form, showed coexistent PTC (27.6%). HT and PTC coexisted in several morphological, immunohistochemical, and biomolecular aspects; increased incidence of PTC in HT patients might therefore indicate that HT is a precursor of thyroid cancer. Further studies are required, however, in order to confirm this hypothesis; until then, HT patients should undergo careful clinical and technical follow-up.
Calogero Cipolla; Luigi Sandonato; Giuseppa Graceffa; Salvatore Fricano; Adriana Torcivia; Salvatore Vieni; Stefania Latteri; Mario Adelfio Latteri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  71     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  874-8     Citation Subset:  IM    
University of Palermo, Department of Oncology, Division of General and Oncological Surgery Policlinico "P. Giaccone" Palermo, Italy.
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MeSH Terms
Adenocarcinoma, Papillary / complications*,  surgery
Hashimoto Disease / complications*,  surgery
Middle Aged
Retrospective Studies
Thyroid Neoplasms / complications*,  surgery

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