Document Detail


Hashimoto's thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records.
MedLine Citation:
PMID:  23151083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hashimoto's thyroiditis is now considered the most prevalent autoimmune disease, as well as the most common endocrine disorder. It was initially described in 1912, but only rarely reported until the early 1950s. To celebrate this centennial, we reviewed the surgical pathology archives of the Johns Hopkins hospital for cases of Hashimoto's thyroiditis, spanning the period from May 1889 to October 2012. Approximately 15,000 thyroidectomies were performed at this hospital over 124 years. The first surgical case was reported in 1942, 30 years after the original description. Then, 867 cases of Hashimoto's thyroiditis were seen from 1942 to 2012, representing 6% of all thyroidectomies. Hashimoto's thyroiditis was the sole pathological finding in 462 cases; it accompanied other thyroid pathologies in the remaining 405 cases. The most commonly associated pathology was papillary thyroid cancer, an association that increased significantly during the last two decades. The most common indication for thyroidectomy was a thyroid nodule that was cytologically suspicious for malignancy. Hashimoto's thyroiditis remains a widespread, intriguing, and multifaceted disease of unknown etiology one century after its description. Advances in the understanding of its pathogenesis and preoperative diagnosis will improve recognition and treatment of this disorder, and may one day lead to its prevention.
Authors:
Patrizio Caturegli; Alessandra De Remigis; Kelly Chuang; Marieme Dembele; Akiko Iwama; Shintaro Iwama
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  23     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-07-29     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Baltimore
Carcinoma / complications,  pathology
Hashimoto Disease / complications,  history,  pathology*,  surgery
History, 19th Century
History, 20th Century
History, 21st Century
Hospital Records
Humans
Thyroid Diseases / pathology
Thyroid Gland / pathology
Thyroid Neoplasms / complications,  pathology
Thyroidectomy
Grant Support
ID/Acronym/Agency:
DK55670/DK/NIDDK NIH HHS; P30 DK079637/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Thyroid. 2013 Sep;23(9):1180-1   [PMID:  23607293 ]
Thyroid. 2013 Feb;23(2):135-6   [PMID:  23398159 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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