| Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? | |
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MedLine Citation:
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PMID: 15327037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in mean magnetic resonance imaging (MRI)-derived measurements between patient groups are often used to determine outcomes in therapeutic trials and other longitudinal studies of multiple sclerosis (MS). However, in day-to-day clinical practice the changes within individual patients may also be of interest In this paper, we estimated the measurement error of an automated brain tissue quantification algorithm and determined the thresholds for statistically significant change of MRI-derived T2 lesion volume and brain atrophy in individual patients. Twenty patients with MS were scanned twice within 30 min. Brain tissue volumes were measured using the computer algorithm. Brain atrophy was estimated by calculation of brain parenchymal fraction. The threshold of change between repeated scans that represented statistically significant change beyond measurement error with 95% certainty was 0.65 mL for T2 lesion burden and 0.0056 for brain parenchymal fraction. Changes in lesion burden and brain atrophy below these thresholds can be safely (with 95% certainty) explained by measurement variability alone. These values provide clinical neurologists with a useful reference to interpret MRI-derived measures in individual patients. |
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Authors:
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Xingchang Wei; Charles R G Guttmann; Simon K Warfield; Michael Eliasziw; J Ross Mitchell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 10 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-25 Completed Date: 2005-02-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 402-6 Citation Subset: IM |
Affiliation:
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Seaman Family MR Research Center, Departments of Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Artifacts Atrophy Brain / pathology* Diagnosis, Computer-Assisted Differential Threshold Humans Magnetic Resonance Imaging* Multiple Sclerosis, Chronic Progressive / diagnosis* Multiple Sclerosis, Relapsing-Remitting / diagnosis* |
| Grant Support | |
ID/Acronym/Agency:
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P01AG004953/AG/NIA NIH HHS; P41RR013218/RR/NCRR NIH HHS; R01CA086879/CA/NCI NIH HHS; R01NS035142/NS/NINDS NIH HHS; R21 MH67054/MH/NIMH NIH HHS; R44MH057200/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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