| Has blood glucose level measured on admission to hospital in a patient with acute pancreatitis any prognostic value? | |
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MedLine Citation:
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PMID: 12120199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Early detection of pancreatic necrosis allows better management of the disease. Contrast-enhanced computed tomography (CT) as the gold standard for detecting pancreatic necrosis is expensive. AIM OF THE STUDY: This study was to evaluate for the first time whether blood glucose estimation on hospital admission--a simple, cheap, readily available laboratory parameter--may detect pancreatic necrosis and have prognostic value in acute pancreatitis. METHODS: Single blood glucose estimation upon hospital admission was evaluated prospectively for detecting pancreatic necrosis and as a prognostic indicator. The study included 241 nondiabetic patients with a first attack of acute pancreatitis. All underwent CT within 72 h of admission. RESULTS: High blood glucose (> 125 mg/dl) correlated significantly with complex high clinical and biochemical prognostic scores (Ranson, Imrie), a high Balthazar score, pancreatic pseudocysts, and a long hospital stay, but not with organ failure, indication for artificial ventilation, dialysis, surgery, length of intensive care, and mortality. Pancreatic necrosis detection sensitivity of high blood glucose was 83%, specificity 49%, positive predictive value 28%, and negative predictive value 92%. CONCLUSION: A patient with normal blood glucose on admission is unlikely to have pancreatic necrosis. Contrast-enhanced CT would not be needed unless the patient fails to improve. |
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Authors:
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P G Lankisch; T Blum; A Bruns; M Dröge; G Brinkmann; K Struckmann; M Nauck; P Maisonneuve; A B Lowenfels |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 1 ISSN: 1424-3903 ISO Abbreviation: Pancreatology Publication Date: 2001 |
Date Detail:
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Created Date: 2002-07-17 Completed Date: 2002-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 224-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Municipal Clinic of Lüneburg. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Blood Glucose / metabolism* Diagnostic Tests, Routine* Female Humans Male Middle Aged Pancreatitis / blood, diagnosis* Predictive Value of Tests Prognosis Prospective Studies Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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