| Has the prevalence of congenital abnormalities after intracytoplasmic sperm injection increased? The Leuven data 1994-2000 and a review of the literature. | |
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MedLine Citation:
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PMID: 20110727 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Although intracytoplasmic sperm injection (ICSI) is now accepted as the treatment of choice for severe male infertility, concerns about its safety and the potential risks for the offspring remain. We reviewed the literature with respect to the prevalence of major congenital malformations after the ICSI technique and supplemented these data with the results of a prospective follow-up study performed in our center. METHODS: From January 1994 till June 2000, 776 ICSI cycles were carried out at the Leuven University Fertility Center. The resulting pregnancies (n = 172) were followed for biochemical and obstetrical parameters, prenatal diagnosis and congenital abnormalities. RESULTS: A total of 134/172 (78%) ongoing pregnancies resulted in 132 deliveries of 166 live born children. Two terminations of pregnancy were carried out due to the presence of major congenital anomalies, diagnosed at prenatal ultrasound. Prenatal diagnosis was carried out in 55 fetuses. Two de novo chromosomal aberrations were found. Major congenital abnormalities were observed at birth in 9/150 (6.0%) children. The total malformation rate was 6.5%. CONCLUSIONS: The prevalence of congenital abnormalities in children born after ICSI in our center (6.5%) was comparable to the prevalence of congenital abnormalities after ICSI reported in the literature. |
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Authors:
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An Hindryckx; Karen Peeraer; Sophie Debrock; Eric Legius; Francis de Zegher; Inge Francois; Dirk Vanderschueren; Koen Demyttenaere; Anna Rijkers; Thomas D'Hooghe |
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Publication Detail:
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Type: Journal Article Date: 2010-01-29 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 70 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 11-22 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Leuven University Fertility Center, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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