| Harvesting peripheral blood progenitor cells from healthy donors: retrospective comparison of filgrastim and lenograstim. | |
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MedLine Citation:
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PMID: 15892086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mobilization of CD34+ into peripheral blood is attained by either glycosylated (lenograstim) or non-glycosylated recombinant G-CSF (filgrastim). 101 donors, 57 males, median age 42 years (range 16-63) entered this retrospective study. Group I (55 cases) received filgrastim and group II lenograstim subcutaneously for 5-6 days. The peak number of CD34+ cells/microl blood observed on day 4 and 5 was not significantly different in the two groups. No differences were shown in terms of both circulating CFU-GM at the time of harvesting and CD34+ target of collection. The most frequent side effects were bone pain (18.2% grade I; 36.4% grade II, 7.3% grade III), headache (18.2%), nausea (9.1%), fever (5.5%) and a mild splenomegaly (> 2 cm) (5.5%) in filgrastim group, and bone pain (37.0% grade I, 26.1% grade II, 2.2% grade III), headache (17.4%), nausea (15.2%), fever (4.4%) and a mild splenomegaly (4.3%) in lenograstim group, respectively. CD34+ collection was associated with thrombocytopenia, which was not significantly different between the two groups. No donor in either group developed long-term adverse effects. We conclude that both G-CSFs are comparable in terms of CD34+ cell collection, safety and tolerability. |
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Authors:
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Massimo Martino; Giuseppe Console; Giuseppe Irrera; Ida Callea; Antonia Condemi; Antonella Dattola; Giuseppe Messina; Antonella Pontari; Giulia Pucci; Giuseppe Furlò; Giuseppe Bresolin; Pasquale Iacopino; Fortunato Morabito |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 20 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-20 Completed Date: 2005-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: United States |
Other Details:
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Languages: eng Pagination: 129-36 Citation Subset: IM |
Copyright Information:
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Copyright 2005 Wiley-Liss, Inc |
Affiliation:
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Bone Marrow Transplant Unit, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy. massimartino@tin.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic Adolescent Adult Antigens, CD34* / blood Cell Separation* / methods Female Filgrastim / administration & dosage*, adverse effects Granulocyte Colony-Stimulating Factor / administration & dosage*, adverse effects Hematopoietic Stem Cell Mobilization* / methods Hematopoietic Stem Cells* / cytology, physiology Humans Male Middle Aged Recombinant Proteins / administration & dosage, adverse effects Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antigens, CD34; 0/Recombinant Proteins; 121181-53-1/Filgrastim; 135968-09-1/lenograstim; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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