Document Detail


Harvesting peripheral blood progenitor cells from healthy donors: retrospective comparison of filgrastim and lenograstim.
MedLine Citation:
PMID:  15892086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mobilization of CD34+ into peripheral blood is attained by either glycosylated (lenograstim) or non-glycosylated recombinant G-CSF (filgrastim). 101 donors, 57 males, median age 42 years (range 16-63) entered this retrospective study. Group I (55 cases) received filgrastim and group II lenograstim subcutaneously for 5-6 days. The peak number of CD34+ cells/microl blood observed on day 4 and 5 was not significantly different in the two groups. No differences were shown in terms of both circulating CFU-GM at the time of harvesting and CD34+ target of collection. The most frequent side effects were bone pain (18.2% grade I; 36.4% grade II, 7.3% grade III), headache (18.2%), nausea (9.1%), fever (5.5%) and a mild splenomegaly (> 2 cm) (5.5%) in filgrastim group, and bone pain (37.0% grade I, 26.1% grade II, 2.2% grade III), headache (17.4%), nausea (15.2%), fever (4.4%) and a mild splenomegaly (4.3%) in lenograstim group, respectively. CD34+ collection was associated with thrombocytopenia, which was not significantly different between the two groups. No donor in either group developed long-term adverse effects. We conclude that both G-CSFs are comparable in terms of CD34+ cell collection, safety and tolerability.
Authors:
Massimo Martino; Giuseppe Console; Giuseppe Irrera; Ida Callea; Antonia Condemi; Antonella Dattola; Giuseppe Messina; Antonella Pontari; Giulia Pucci; Giuseppe Furlò; Giuseppe Bresolin; Pasquale Iacopino; Fortunato Morabito
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  20     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-20     Completed Date:  2005-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc
Affiliation:
Bone Marrow Transplant Unit, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy. massimartino@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic
Adolescent
Adult
Antigens, CD34* / blood
Cell Separation* / methods
Female
Filgrastim / administration & dosage*,  adverse effects
Granulocyte Colony-Stimulating Factor / administration & dosage*,  adverse effects
Hematopoietic Stem Cell Mobilization* / methods
Hematopoietic Stem Cells* / cytology,  physiology
Humans
Male
Middle Aged
Recombinant Proteins / administration & dosage,  adverse effects
Retrospective Studies
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens, CD34; 0/Recombinant Proteins; 121181-53-1/Filgrastim; 135968-09-1/lenograstim; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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