Document Detail

Harry Lee Parker and paroxysmal dysarthria and ataxia.
MedLine Citation:
PMID:  23319475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review descriptions of paroxysmal dysarthria and ataxia in multiple sclerosis (MS), with special attention given to Parker and his 1946 case series.
METHODS: Evaluation of original publications describing paroxysmal dysarthria and ataxia, bibliographic information, writings, and unpublished letters from the Mayo Clinic Historical Unit.
RESULTS: In 1940, Störring described a patient with MS with paroxysmal symptoms that included dizziness and trouble speaking, but also unilateral extremity weakness. In 1946, Parker published a series of 11 patients with paroxysmal dysarthria and ataxia. Six of these patients had MS, and he recognized this phenomenon as a manifestation of the disease. The term "paroxysmal dysarthria and ataxia" was first used in 1959 by Andermann and colleagues. Since that time, paroxysmal dysarthria and ataxia has become a well-recognized phenomenon in MS. More recent reports have suggested that the responsible lesion is located in the midbrain, near or involving the red nucleus.
CONCLUSIONS: Parker was the first to accurately describe paroxysmal dysarthria and ataxia in patients with MS.
James P Klaas; David B Burkholder; Wolfgang Singer; Christopher J Boes
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Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-07     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  AIM; IM    
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MeSH Terms
Ataxia / etiology*
Dysarthria / etiology*
History, 20th Century
Multiple Sclerosis / complications*
Neurology / history*
Personal Name Subject
Personal Name Subject:
Harry Parker

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