| Harnessing the power of the endosome to regulate neural development. | |
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MedLine Citation:
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PMID: 22578496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond regulating entry of essential nutrients. In this review, we discuss the cell biological principles of endosomal trafficking, the neuronal adaptations to endosomal organization, and the role of endosomal trafficking in neural development. In particular, we consider how cell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endosomal tricks: dynamic modulation of receptor levels by endocytosis and recycling, cargo-specific responses via cargo-specific endocytic regulators, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regulation of ligand processing and trafficking. |
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Authors:
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Chan Choo Yap; Bettina Winckler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neuron Volume: 74 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-14 Completed Date: 2012-07-12 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 440-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neuroscience, University of Virginia, 409 Lane Road, Charlottesville, VA 22908, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endocytosis / physiology Endosomes / physiology* Humans Models, Biological Neurogenesis / physiology* Neurons / physiology*, ultrastructure Protein Transport / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM086913/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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