Document Detail

Harnessing the power of the endosome to regulate neural development.
MedLine Citation:
PMID:  22578496     Owner:  NLM     Status:  MEDLINE    
Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond regulating entry of essential nutrients. In this review, we discuss the cell biological principles of endosomal trafficking, the neuronal adaptations to endosomal organization, and the role of endosomal trafficking in neural development. In particular, we consider how cell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endosomal tricks: dynamic modulation of receptor levels by endocytosis and recycling, cargo-specific responses via cargo-specific endocytic regulators, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regulation of ligand processing and trafficking.
Chan Choo Yap; Bettina Winckler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  74     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-07-12     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Neuroscience, University of Virginia, 409 Lane Road, Charlottesville, VA 22908, USA.
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MeSH Terms
Endocytosis / physiology
Endosomes / physiology*
Models, Biological
Neurogenesis / physiology*
Neurons / physiology*,  ultrastructure
Protein Transport / physiology
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