Document Detail


Harnessing the Power of the Immune System to Target Cancer.
MedLine Citation:
PMID:  23092383     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
For many years, immunotherapeutic approaches for cancer held more promise than actual clinical benefit for the majority of patients. However, several recent key advances in tumor immunology have now turned the tide in favor of immunotherapy for the treatment of many different cancer types. In this review, we describe four of the most effective immunotherapeutic approaches currently used in the clinic: cancer vaccines, immunostimulatory agents, adoptive T cell therapy, and immune checkpoint blockade. In addition, we discuss some of the most promising future strategies that aim to utilize multiple immunotherapies or combine them with other approaches to more effectively target cancer. Expected final online publication date for the Annual Review of Medicine Volume 64 is January 07, 2013. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
Authors:
Gregory Lizée; Willem W Overwijk; Laszlo Radvanyi; Jianjun Gao; Padmanee Sharma; Patrick Hwu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-22
Journal Detail:
Title:  Annual review of medicine     Volume:  -     ISSN:  1545-326X     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Melanoma Medical Oncology, The Center for Cancer Immunology Research, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030.
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