| Harnessing Nanoparticles to Improve Toxicity after Head and Neck Radiation. | |
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MedLine Citation:
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PMID: 22248817 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Evaluate cerium oxide (CeO(2)) nanoparticles' ability to decrease xerostomia and radiation-induce dermatitis in mice after head and neck radiation. EXPERIMENTAL DESIGN: Mice were irradiated using an IC160 X-ray system. Two cohorts: (A) No-radiation and (B) 30 Gy/6 fractions, were randomized into three groups: (1) Saline, (2) 15 nM CeO(2) and (3) 15 µM CeO(2). Stimulated salivary flow and radiation-induced dermatitis were evaluated post-radiation. RESULTS: Stimulated sialometry demonstrated improved salivary production in all CeO(2) groups compared to controls (flow: 204 vs. 115 μL/10 min, p=0.0002). One week post-radiation, G-III dermatitis decreased in the 15 µM group compared to controls (10% vs. 100% incidence, respectively). There was decreased skin hyperpigmentation at 12 weeks in the 15 µM group compared to 15 nM and non-CeO(2) groups (50, 70, and 90% G-II, respectively). DISCUSSION: This study suggests that CeO(2) may be radioprotective for salivary production, while reducing G-III dermatitis and skin hyperpigmentation incidence. CeO(2) as radioprotectant may be a feasible concept during radiotherapy. |
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Authors:
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Rafael A Madero-Visbal; Beatrice E Alvarado; Jimmie F Colon; Cheryl H Baker; Melissa S Wason; Beth Isley; Sudipta Seal; Chris M Lee; Soumen Das; Rafael Mañon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: - ISSN: 1549-9642 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Cancer Research Institute - MD Anderson Cancer Center Orlando, Orlando FL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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