Document Detail

Harness the power: new insights into the inhibition of YAP/Yorkie.
MedLine Citation:
PMID:  19289076     Owner:  NLM     Status:  MEDLINE    
YAP/Yorkie (Yki) is a transcriptional coactivator that controls organ size; dysregulation causes tumorigenesis by stimulating cell proliferation and inhibiting apoptosis. The Hippo pathway restrains YAP/Yki activity, but it remains unclear how cellular regulation at the plasma membrane influences the Hippo-YAP/Yki pathway. Two papers in this issue on Developmental Cell, by Badouel et al. and Nishioka et al., address this question.
Bin Zhao; Qun-Ying Lei; Kun-Liang Guan
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  16     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-04-02     Revised Date:  2009-05-22    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-2     Citation Subset:  IM    
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0815, USA.
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MeSH Terms
Apoptosis Regulatory Proteins / antagonists & inhibitors*
Drosophila Proteins / antagonists & inhibitors*,  metabolism
Intracellular Signaling Peptides and Proteins / metabolism
Models, Biological
Nuclear Proteins / antagonists & inhibitors*
Protein-Serine-Threonine Kinases / metabolism
Signal Transduction
Trans-Activators / antagonists & inhibitors*
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Drosophila Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/Trans-Activators; 0/Yorkie protein, Drosophila; EC Kinases; EC protein, Drosophila
Comment On:
Dev Cell. 2009 Mar;16(3):398-410   [PMID:  19289085 ]
Dev Cell. 2009 Mar;16(3):411-20   [PMID:  19289086 ]

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