Document Detail


The harmonies played by TGF-β in stem cell biology.
MedLine Citation:
PMID:  23217421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.
Authors:
Naoki Oshimori; Elaine Fuchs
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell stem cell     Volume:  11     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-07-30     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  751-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / cytology,  metabolism
Animals
Gene Regulatory Networks / genetics
Humans
Organ Specificity
Signal Transduction / genetics
Stem Cells / metabolism*
Transforming Growth Factor beta / metabolism*
Grant Support
ID/Acronym/Agency:
R01 AR031737/AR/NIAMS NIH HHS; R01 AR050452/AR/NIAMS NIH HHS; R01-AR050452/AR/NIAMS NIH HHS; R01-AR31737/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta
Comments/Corrections

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