| Harmonic Analysis of Noninvasively Recorded Arterial Pressure Waveforms in Healthy Bonnet Macaques (Macaca radiata). | |
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MedLine Citation:
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PMID: 21333168 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To characterize primate arterial waveforms, we prospectively studied 38 bonnet macaques (Macaca radiata; 25 female, 13 ± 4 y). Brachial artery waveforms were recorded from these animals by applanation tonometry and were decomposed into harmonics by using Fourier analysis. The ratio of individual to total harmonic amplitude (H:T) was derived from frequency spectra. Left ventricular (LV) mass, ejection fraction, fractional shortening, septal wall thickness, posterior wall thickness, LV end-diastolic diameter, and LV end-systolic diameter were obtained by echocardiography in all 38 monkeys. Blood pressure was obtained by sphygmomanometry. The fundamental frequency was 2.76 cycles/s. Harmonics ranged from 5 to 14. Indexed LV mass was inversely correlated with third H:T and second H:T but not with systolic or diastolic blood pressure. In addition, the third H:T was inversely correlated with septal wall thickness, posterior wall thickness, and LV end-diastolic diameter, whereas second H:T was inversely correlated with LV end-diastolic diameter. Heart rate was inversely correlated with eighth H:T. On multivariate analysis adjusting for age, gender, weight, and length, only third H:T was an independent predictor of LV mass. Harmonic analysis of arterial waveforms may provide information pertaining to LV mass. Lower H:T ratios (second and third) are related to LV mass, whereas higher H:T (eighth) is related to heart rate. |
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Authors:
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Oladipupo Olafiranye; Louis Salciccioli; Haroon Kamran; Mark Stewart; John Carter; Jason M Lazar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Association for Laboratory Animal Science : JAALAS Volume: 50 ISSN: 1559-6109 ISO Abbreviation: J. Am. Assoc. Lab. Anim. Sci. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269489 Medline TA: J Am Assoc Lab Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 79-83 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, New York, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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