Document Detail

Harmonic analysis of noninvasively recorded arterial pressure waveforms in healthy bonnet macaques (Macaca radiata).
MedLine Citation:
PMID:  21333168     Owner:  NLM     Status:  MEDLINE    
To characterize primate arterial waveforms, we prospectively studied 38 bonnet macaques (Macaca radiata; 25 female, 13 ± 4 y). Brachial artery waveforms were recorded from these animals by applanation tonometry and were decomposed into harmonics by using Fourier analysis. The ratio of individual to total harmonic amplitude (H:T) was derived from frequency spectra. Left ventricular (LV) mass, ejection fraction, fractional shortening, septal wall thickness, posterior wall thickness, LV end-diastolic diameter, and LV end-systolic diameter were obtained by echocardiography in all 38 monkeys. Blood pressure was obtained by sphygmomanometry. The fundamental frequency was 2.76 cycles/s. Harmonics ranged from 5 to 14. Indexed LV mass was inversely correlated with third H:T and second H:T but not with systolic or diastolic blood pressure. In addition, the third H:T was inversely correlated with septal wall thickness, posterior wall thickness, and LV end-diastolic diameter, whereas second H:T was inversely correlated with LV end-diastolic diameter. Heart rate was inversely correlated with eighth H:T. On multivariate analysis adjusting for age, gender, weight, and length, only third H:T was an independent predictor of LV mass. Harmonic analysis of arterial waveforms may provide information pertaining to LV mass. Lower H:T ratios (second and third) are related to LV mass, whereas higher H:T (eighth) is related to heart rate.
Oladipupo Olafiranye; Louis Salciccioli; Haroon Kamran; Mark Stewart; John Carter; Jason M Lazar
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  50     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-08-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Division of Cardiovascular Medicine, Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, New York, USA.
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MeSH Terms
Blood Pressure
Blood Pressure Determination / methods,  veterinary*
Brachial Artery / physiology*
Fourier Analysis
Macaca radiata / physiology*
Manometry / methods,  veterinary*

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