Document Detail


Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease.
MedLine Citation:
PMID:  20399524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Adipose tissue is an important source of cytokines. Excess weight is an independent risk factor for steatosis, acute alcoholic hepatitis (AAH), and cirrhosis in patients with alcoholic liver disease (ALD). In this study, we investigated the role of adipose tissue in human ALD.
PATIENTS AND METHODS: Fifty patients with ALD underwent liver and abdominal subcutaneous adipose tissue biopsies and supplied blood samples for the investigation of cytokine gene expression and secretion, as well as liver histology.
RESULTS: The levels of TNF-alpha and IL-10 in adipose tissue were higher in patients with AAH. IL-10 level in adipose tissue was also correlated with fibrosis score. TNF-alpha gene expression in adipose tissue was correlated with Maddrey score, blood C-reactive protein (CRP) concentration and liver IL-6 concentration. IL-6 production levels in the liver were higher in patients with AAH and correlated with AAH score, liver histological lesions, liver TNF-alpha concentration, Maddrey score, and blood CRP concentration. Plasma concentrations of soluble forms of TNF-receptor were correlated with inflammatory lesions in the liver, Maddrey score and fibrosis score.
CONCLUSION: In patients with ALD, inflammation occurs not only in the liver, but also in the adipose tissue. Adipose tissue inflammation is correlated with the severity of pathological features in the liver. Our findings may account for the harmful interactions between body mass index, AAH, fibrosis, and cirrhosis in alcoholic patients.
Authors:
Sylvie Naveau; Anne-Marie Cassard-Doulcier; Micheline Njiké-Nakseu; Laurence Bouchet-Delbos; Nadège Barri-Ova; Hédia Boujedidi; Barbara Dauvois; Axel Balian; Sophie Maitre; Sophie Prévot; Ibrahim Dagher; Hélène Agostini; Liliane Grangeot-Keros; Dominique Emilie; Gabriel Perlemuter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-24
Journal Detail:
Title:  Journal of hepatology     Volume:  52     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-23     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  895-902     Citation Subset:  IM    
Copyright Information:
Copyright 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Affiliation:
AP-HP, Hôpital Antoine Béclère, Service d'hépato-gastroentérologie, Clamart F-92140, France.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Body Mass Index
C-Reactive Protein / metabolism
Fatty Liver, Alcoholic / epidemiology,  immunology,  pathology*
Female
Gene Expression / immunology
Hepatitis / epidemiology,  immunology,  pathology*
Humans
Inflammation / epidemiology,  immunology,  pathology
Interleukin-10 / blood,  genetics
Interleukin-6 / blood,  genetics
Intra-Abdominal Fat / immunology,  metabolism,  pathology*
Liver / immunology,  pathology*
Liver Cirrhosis / epidemiology,  immunology,  pathology
Male
Middle Aged
Prospective Studies
Risk Factors
Severity of Illness Index
Subcutaneous Fat / immunology,  metabolism,  pathology*
Tumor Necrosis Factor-alpha / blood,  genetics
Chemical
Reg. No./Substance:
0/IL10 protein, human; 0/IL6 protein, human; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 9007-41-4/C-Reactive Protein

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