Document Detail


Harmful effect of land-based endurance exercise in rats with diabetic nerve.
MedLine Citation:
PMID:  20142779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Repetitive limb movements made during aerobic exercises, such as walking and jogging that are frequently prescribed for diabetes control, can induce nerve strain, which has been reported to induce nerve ischemia. Nerves in a diabetic background are more vulnerable to ischemia. We investigated the effects of repetitive treadmill and swimming exercises on nerves in diabetic rats.
METHODS: Rats with diabetic neuropathy were randomly allocated to one of three groups, namely, control (n = 7), treadmill (n = 8), and swimming (n = 8) groups. After 12 wk of exercise, sural and sciatic nerves were harvested and analyzed by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and Western blotting.
RESULTS: In sural nerves, percentages of TUNEL-positive cells and BAX/GAPDH level were higher in the treadmill than that in the swimming group. In sciatic nerves, there was no significant difference among three groups.
CONCLUSIONS: : Endurance exercises increase Schwann cell apoptosis in distal peripheral nerves. Greater loadings during exercise were found to increase Schwann cell apoptosis. Land-based endurance exercises may have a harmful effect on peripheral nerves in certain individuals with diabetes.
Authors:
Won-Seok Kim; Shi-Uk Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  42     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1625-31     Citation Subset:  IM; S    
Affiliation:
Department of Physical Medicine and Rehabilitation, College of Medicine, Seoul National University, Boramae Medical Center, 395 Shindaebang 2 dong, Dongjak ku, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology
Diabetic Nephropathies / pathology,  physiopathology*
Exercise Test
Female
Glyceraldehyde-3-Phosphate Dehydrogenases / analysis
In Situ Nick-End Labeling
Physical Conditioning, Animal
Physical Endurance / physiology*
Rats
Rats, Sprague-Dawley
Schwann Cells / pathology
Sciatic Nerve / physiopathology
Sural Nerve / physiopathology
Swimming / physiology
bcl-2-Associated X Protein / analysis
Chemical
Reg. No./Substance:
0/bcl-2-Associated X Protein; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases

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