Document Detail


The Hardy-Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV.
MedLine Citation:
PMID:  6306469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is substantial evidence that oncogenes (v-onc) of acute transforming retroviruses have been acquired by transduction of cellular genes (c-onc) with retroviruses. Feline leukaemia virus (FeLV)-associated feline fibrosarcomas have proven to be extremely useful for the isolation of acute transforming retroviruses of a mammalian species. Three different v-onc genes have been identified in five acute transforming feline retroviruses. The Susan McDonough feline sarcoma virus (SMFeSV) contains the oncogene fms (ref. 4). The Snyder-Theilen (ST) and Gardner-Arnstein (GA) FeSVs contain the oncogene fes (ref. 4), which is homologous to the oncogene fps of the avian sarcoma viruses FSV, RRCII, PRCIV and 16L (refs 7, 8). The v-onc sequences of the Parodi-Irgens (PI) FeSV have recently been found to be homologous with the v-sis sequences of the simian sarcoma virus. We report here the isolation of another acute transforming feline retrovirus from a naturally occurring feline fibrosarcoma, designated the Hardy-Zuckerman 2 feline sarcoma virus (HZ2-FeSV) and demonstrate that the HZ2-FeSV and Abelson murine leukaemia virus (A-MuLV) have homologous oncogenes.
Authors:
P Besmer; W D Hardy; E E Zuckerman; P Bergold; L Lederman; H W Snyder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  303     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abelson murine leukemia virus / genetics*
Leukemia Virus, Murine / genetics*
Nucleic Acid Hybridization
Oncogenes*
Sarcoma Viruses, Murine / genetics*
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
CA-08748/CA/NCI NIH HHS; CA-16599/CA/NCI NIH HHS; CA-32926/CA/NCI NIH HHS

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