| Haptoglobin therapy for possible prevention of renal failure following thermal injury: a clinical study. | |
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MedLine Citation:
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PMID: 3989885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemolysis does not necessarily result in acute renal failure in severely burned patients, but free serum hemoglobin may play some important role in the development of renal damage. This controlled study of the effects of haptoglobin administration in severely burned patients presenting with hemoglobinuria produced the following results: As long as free hemoglobin was present in the plasma, free serum haptoglobin remained undetectable. Free serum hemoglobin dropped rapidly after haptoglobin treatment, whereas the free serum hemoglobin levels in control patients remained unchanged for at least 12 hours. The time required for macroscopic hemoglobinuria to clear showed a statistically significant difference between the haptoglobin-treated patients and the control patients. Some patients among the haptoglobin-treated group had prolonged hemolysis and hemoglobinuria which might have cleared with additional doses of haptoglobin. |
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Authors:
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T Yoshioka; T Sugimoto; T Ukai; T Oshiro |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 25 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-06-06 Completed Date: 1985-06-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 281-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Burns / complications*, immunology Haptoglobins / therapeutic use* Hemoglobins / analysis Hemoglobinuria / drug therapy, etiology Hemolysis Humans Kidney Failure, Acute / etiology, prevention & control* Male Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Haptoglobins; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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