Document Detail

Haptoglobin polymorphism in a HIV-1 seropositive Brazilian population.
MedLine Citation:
PMID:  16644889     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Haptoglobin (Hp) is a plasma protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinctive efficiencies in their activities and have been related to susceptibility and outcome in different diseases, including HIV infection.
OBJECTIVE: To compare Hp genotype distribution between HIV-1 seropositive patients and healthy controls.
METHODS: 387 Brazilian HIV-1 seropositive patients, subclassified as A, B, and C according to the Centers for Disease Control, were compared with 142 healthy controls. The influence of the polymorphism on iron status (serum iron, ferritin, transferrin, transferrin saturation), acute phase proteins (Hp, C reactive protein, fibrinogen, albumin), the HIV-1 viral load, and CD4+ T lymphocyte counts was examined.
RESULTS: Apart from finding lower Hp concentrations among individuals with genotype Hp2-2, no other significant difference was observed.
CONCLUSIONS: No association was found between Hp genotype and either HIV status or indices of HIV progression.
T R Zaccariotto; E T Rosim; D Melo; P M D Garcia; R R Munhoz; F H Aoki; M de Fatima Sonati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  59     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-07-13     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-3     Citation Subset:  AIM; IM    
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MeSH Terms
Case-Control Studies
Disease Progression
HIV Seropositivity / blood*
Haptoglobins / genetics*
Middle Aged
Polymorphism, Genetic*
Reg. No./Substance:

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