Document Detail

Haptoglobin phenotype and reproductive success in repeated spontaneous abortion.
MedLine Citation:
PMID:  19356838     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the reproductive success of couples with a history of repeated spontaneous abortion (RSA) with respect to the haptoglobin (Hp) phenotypes of both the wife and husband. STUDY DESIGN: This study examined maternal and paternal Hp in 194 couples with primary and secondary RSA recruited from the Center for Reproductive Disorders of the Institute of Obstetrics and Gynaecology at the University of Rome, La Sapienza. Reproductive success was indicated by the presence of at least one live-born infant after more than 5 years of follow-up. RESULTS: The proportion of wives carrying Hp2/1 phenotype and with at least one live-born infant is significantly lower than that of wives without a live-born infant. Moreover, the proportion of couples in which both wife and husband possess the Hp2/1 phenotype is much lower in those with at least a live-born infant than in those without a live-born infant. Both maternal and paternal Hp contribute to reproductive success. However, the contribution of maternal Hp appears stronger than that of paternal Hp. CONCLUSIONS: Hp may play an important role in implantation and/or embryo survival. Couples in which both partners carry the Hp2/1 phenotype have a low probability of producing a live-born infant.
F Gloria-Bottini; A Magrini; A Amante; M Nicotra; E Bottini
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Publication Detail:
Type:  Journal Article     Date:  2009-04-07
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  144     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-19     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy.
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MeSH Terms
Abortion, Habitual / genetics*
Haptoglobins / genetics*
Reg. No./Substance:

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