Document Detail


Haptoglobin: an immunoregulatory role in tuberculosis?
MedLine Citation:
PMID:  3984037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A significant correlation was found between levels of haptoglobin in sera from Indonesian patients with tuberculosis and the extent to which these sera suppressed mitogen-driven activation of normal lymphocytes in vitro. As in a previous study we showed that there was an inverse relationship between haptoglobin levels and the circulating lymphocyte count in the same group of patients, it is now suggested that this protein has an immunoregulatory role in tuberculosis. Similar observations have been made by other workers on patients with cancer. There was no difference in the distribution of the 3 allotypes of haptoglobin in patients and healthy subjects nor was there any association between such allotypes and the lymphocyte count, the dermal reactivity to tuberculin or the degree of suppression.
Authors:
J M Grange; T Kardjito; J S Beck; O Ebeid; W Köhler; O Prokop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tubercle     Volume:  66     ISSN:  0041-3879     ISO Abbreviation:  Tubercle     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-09     Completed Date:  1985-05-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1273730     Medline TA:  Tubercle     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Agglutination Tests
Complement System Proteins / analysis
Electrophoresis
Haptoglobins / analysis,  immunology*
Humans
Immunoglobulins / analysis
Lymphocyte Activation
Skin Tests
Tuberculosis, Pulmonary / immunology*
Chemical
Reg. No./Substance:
0/Haptoglobins; 0/Immunoglobulins; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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